Location, location, location: tissue-specific regulation of immune responses
نویسندگان
چکیده
منابع مشابه
Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis
Infectious disease burden remains high [1]. An improved knowledge of host–microorganism interactions is key to delineating disease progression and developing new control and treatment modalities. Microorganisms may be pathogenic (able to cause disease) or non-pathogenic (unable to cause disease). Disease severity is influenced by host and pathogen factors; in particular, pathogens may express d...
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Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
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Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
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Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2013
ISSN: 0741-5400
DOI: 10.1189/jlb.0413207